Improving health is no small task. Given the complexities and interdependence of the landscape, simple cause and effect relationships can be either misleading or difficult to isolate. From the point in 1995 when St. Luke’s Health System sold its medical facilities and created the public foundation known today as Vitalyst Health Foundation, the organization has pursued how to most appropriately invest and leverage the extent of its available resources and assets in concert with those of the community and partners.